Stereoselective Total Synthesis of Decytospolides A and B Starting from D‐Mannitol |
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| Authors: | Malampati Srilatha Biswanath Das |
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| Institution: | 1. Natural Products Chemistry Division, CSIR‐ Indian Institute of Chemical Technology, Hyderabad‐, 500 007, India (phone: +91‐40‐7193434;2. fax: +91‐40‐7160512) |
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| Abstract: | The stereoselective total synthesis of decytospolides A and B, two naturally occurring pyran derivatives, has been achieved using D ‐mannitol as the starting material. The intramolecular oxa‐Michael reaction has been employed to construct the tetrahydropyran ring of the molecules and Weinreb amide formation to generate their side chain with a keto function. |
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| Keywords: | Decytospolides A and B D‐Mannitol Oxa‐Michael reaction Weinreb amide formation |
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