Eupatozansins A – C,Sesquiterpene Lactones from Eupatorium chinense var. tozanense |
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| Authors: | Chia‐Ching Liaw Yao‐Haur Kuo Tsong‐Long Hwang Ya‐Ching Shen |
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| Institution: | 1. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, Republic of China;2. National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China;3. Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan, Republic of China;4. School of Pharmacy, College of Medicine, National Taiwan University, No. 1, Jen‐Ai Road, Sec. 1, Taipei, Taiwan, Republic of China (phone: 886‐2‐2312‐3456 ext. 2226;5. fax: 886‐2‐02‐2391‐9098) |
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| Abstract: | Phytochemical investigation of Eupatorium chinense var. tozanense has resulted in the isolation of three new germacranolides, designated as eupatozansins A–C ( 1 – 3 ), along with five known compounds, (5S,6R,7R,8R)‐8‐angeloyloxy‐2‐oxoguaia‐1(10),3,11(13)‐trien‐12,6‐olide ( 4 ), costunolide ( 5 ), leptocarpin ( 6 ), 2α‐hydroxyeupatolide 8‐O‐angelate ( 7 ), and quercetin ( 8 ). The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high‐resolution mass spectrometry. The in vitro cytotoxic activities of compounds 1 – 8 were evaluated. |
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| Keywords: | Eupatorium chinense var tozanense Eupatozansins A – C Germacranolides Sesquiterpene lactones Cytotoxic activity |
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