Two New Lycopodium Alkaloids from Lycopodium obscurum |
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| Authors: | Ke Pan Jian‐Guang Luo Ling‐Yi Kong |
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| Institution: | 1. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P.?R. China, (phone: +86‐25‐8327?1405;2. fax: +86‐21‐8327 1405) |
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| Abstract: | Two new Lycopodium alkaloids, (+)‐cermizine D N‐oxide ( 1 ) and (8β)‐8‐(acetyloxy)obscurumine A ( 2 ), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All of these alkaloids were tested in an assay for acetylcholine esterase (AChE) inhibitory activity. |
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| Keywords: | Lycopodium obscurum (+)‐Cermizine D N‐oxide Obscurumine A 8β ‐acetoxy‐ Inhibitors Alkaloids Acetylcholine esterase (AChE) |
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