Seco‐Tremulanes from Cultures of the Basidiomycete Flavodon flavus BCC 17421 |
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| Authors: | Masahiko Isaka Somporn Palasarn Sumalee Supothina Kitlada Srichomthong Rattaket Choeyklin |
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| Institution: | 1. +66‐25646700 ext 3554+66‐25646707;2. National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand;3. Biodiversity‐Based Economy Development Office, Bangkok, Thailand |
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| Abstract: | A new seco‐tremulane, 11,12‐epoxy‐5,6‐secotremula‐1,6(13)‐dien‐5,12‐olide ( 1 ), was isolated together with the known compounds, conocenolides A ( 2 ) and B ( 3 ), tremulenediol A ( 4 ), tremulenolide A ( 5 ), and two lanostane triterpenoids, trametenolic acid B ( 6 ), and pinicolic acid A ( 7 ), from cultures of the basidiomycete Flavodon flavus BCC 17421. Interconversion of conocenolides A/B was demonstrated. Compound 1 exhibited weak cytotoxic activities, whereas tremulenediol A showed antiplasmodial activity (IC50 8.6 μg/ml). Pinicolic acid A exhibited activity against herpes simplex virus type‐1 (IC50 15 μg/ml) as well as cytotoxic activities. |
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| Keywords: |
Flavodon flavus
Basidiomycete Tremulane Antiviral activity Antimalarial activity Cytotoxicity |
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