Convenient Synthesis of 1H‐Indol‐1‐yl Boronates via Palladium(0)‐Catalyzed Borylation of Bromo‐1H‐indoles with ‘Pinacolborane’ |
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Authors: | JosefF Stadlwieser MarkusE Dambaur |
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Institution: | Josef F. Stadlwieser,Markus E. Dambaur |
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Abstract: | An atom‐economic Pd0‐catalyzed synthesis of a series of pinacol‐type indolylboronates 3 from the corresponding bromoindole substrates 2 and pinacolborane (pinBH) as borylating agent was elaborated. The optimal catalyst system consisted of a 1 : 2 mixture of Pd(OAc)2] and the ortho‐substituted biphenylphosphine ligand L‐3 (Scheme 4, Table). Our synthetic protocol was applied to the fast, preparative‐scale synthesis of 1‐substituted indolylboronates 3a – h in the presence of different functional groups, and at a catalyst load of only 1 mol‐% of Pd. |
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Keywords: | Borylation Palladium catalysis Boronates 1H‐indol‐1‐yl ‘ Pinacolborane’ Organoboron compounds |
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