| Abstract: | Synthetic Analogues of Low-Molecular-Weight Acyl-polyamine Spider Toxins Low-molecular-weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide-like bond. The syntheses of twelve analogues of spider and wasp toxins are described ( 10a – c , 15a – c , 20a – c , 25a – c ) having the general structure of acyl, arylacyl, or heteroarylacyl → DL -alanyl → ω-aminoacyl → N1-spermidine, with variation in the acyl and the ω-aminoacyl part. |
