Abstract: | A novel, efficient one‐pot approach for the synthesis of furopyrimidine and oxobenzofuran derivatives 4 by a multicomponent reaction of an isocyanide, an aldehyde, and a CH‐acid compound in CH2Cl2 is reported (Scheme 1 and Table). The reactions were completed after 20 h at room temperature. This method has the advantages of high yields, simple methodology, and easy workup. |