Recent advances in optical manipulation of cells and molecules for biological science |
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| Institution: | 1. Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Japan;2. Department of Mechanical Engineering, Toyohashi University of Technology, Japan;3. Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Japan;1. Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA;2. Department of Chemistry, University of California, Riverside, CA 92521-0403, USA;3. Department of Chemistry, Washington University, St. Louis, MO 63130-4889, USA;1. Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan;2. Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Sumiyoshi-ku, Osaka 558-8585, Japan;3. Tianjin Key Laboratory of Optoelectronic Materials and Devices, School of Materials Science and Engineering, Tianjin University of Technology, Xiqing, Tianjin 300384, PR China;1. Department of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita 565-0871, Japan;2. Institute for Molecular Science, National Institutes of Natural Sciences, Okazaki, Aichi, Japan;1. Graduate School of Engineering, Chiba University, Japan;2. Molecular Chirality Research Center, Chiba University, Japan;3. Osaka City University, Japan;4. Department of Applied Physics, Hokkaido University, Japan;1. Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China;2. Department of Civil Engineering, The University of Hong Kong, the Hong Kong Special Administrative Region of China;3. State Key Laboratory of Pollution Control and Resource Reuse, Shanghai Institute of Pollution Control and Ecological Security, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;4. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China |
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| Abstract: | Noninvasive and nondestructive techniques for monitoring and manipulating cells or biomolecules are essential for understanding biological processes. Optical methodologies have been used for the noninvasive and nondestructive monitoring of intracellular molecules and manipulation of cellular activities to elucidate the localization and interactions of these biomolecules. Since the pioneering work of Ashkin, optical trapping has been used to study cellular elasticity and mechanical characteristics of intracellular molecules. In recent years, there has been a substantial amount of research on the optical manipulation of nanometer-sized objects, including the manipulation of the assembly of nanomaterials and the enhancement of optical forces with optical resonance effects. In the study of biomolecular manipulation by optical forces, the functions and roles of biomolecules have been clarified by analyzing the changes in cellular functions induced by manipulation. In this review, we focus on recent studies on optical trapping for the manipulation of living cells or biomolecules and introduce techniques for the manipulation of cellular functions using optical forces. |
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| Keywords: | Optical trapping Optical manipulation Biomolecular systems Fluorescence imaging Nanomaterials |
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