AUGMENTATION OF ULTRAVIOLET ERYTHEMA BY INDOMETHACIN IN ACTINIC PRURIGO: EVIDENCE OF MECHANISM OF PHOTOSENSITIVITY |
| |
Authors: | P M Farr B L Diffey |
| |
Institution: | Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK;Regional Medical Physics Department, Dryburn Hospital, Durham, UK |
| |
Abstract: | Abstract— The effect of topical indomethacin on the intensity of erythema induced by ultraviolet radiation was measured by reflectance spectrophotometry in six patients with actinic prurigo. The intensity of UV-C erythema was decreased by indomethacin in five patients. The intensity of UV-B erythema was increased by indomethacin in five patients, and UV-A erythema was increased by indomethacin in all patients. The increased inflammatory response induced by UV-B and UV-A with indomethacin application was related to erythemal sensitivity at these wavelengths. Topical indomethacin caused no change in the intensity of UV-A erythema in a group of non-photosensitive subjects. That inhibition of cyclo-oxygenase augments the inflammatory response to ultraviolet radiation suggests that lipoxygenase metabolites of arachidonic acid may be involved in the mechanism of photosensitivity in actinic prurigo. |
| |
Keywords: | |
|
|