PHOTOSENSITIZATION WITH BACTERIOCHLORINS |
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| Authors: | David Kessel Kevin M Smith R K Pandey F-Y Shiau Barbara Henderson |
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| Institution: | Departments of Pharmacology and Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA;Department of Chemistry, University of California, Davis, CA 95616, USA;Division of Radiation Biology, Roswell Park Cancer Center, Buffalo, NY 24623, USA |
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| Abstract: | Abstract— Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture. |
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