Insulinomimetic Zn(II) complexes as evaluated by both glucose-uptake activity and inhibition of free fatty acids release in isolated rat adipocytes |
| |
| Authors: | Midori Nishide Yutaka Yoshikawa Eriko U Yoshikawa Kinuyo Matsumoto Hiromu Sakurai Naemi M Kajiwara |
| |
| Institution: | Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University, Kobe, Japan. |
| |
| Abstract: | We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N(2)O(2)), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(alpha-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity. |
| |
| Keywords: | |
|
|
