Synthesis and antiviral activities of some 4,4'-dihydroxytriphenylmethanes |
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Authors: | Mibu Nobuko Yokomizo Kazumi Uyeda Masaru Sumoto Kunihiro |
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Institution: | Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka, Japan. |
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Abstract: | 4,4'-Dihydroxytriphenylmethanes were synthesized using Br?nsted acid or Lewis acid in yields of 24-86% as target compounds for developing antiviral agents. Most of the 4,4'-dihydroxytriphenylmethanes showed significant activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. Higher cytotoxicity was observed generally in halogenated 4,4'-dihydroxytriphenylmethanes (2a-d) than in non-halogenated derivatives. The non-halogenated derivative, 4,4',4"-trihydroxy-3"-methoxytriphenylmethane (3), showed remarkable antiviral activity with an EC(50) value of 1.8 microg/ml. |
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