Isolation of tetraprenyltoluquinols from the brown alga Sargassum thunbergii |
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Authors: | Seo Youngwan Park Ki Eui Kim You Ah Lee Hee-Jung Yoo Jong-Su Ahn Jong-Woong Lee Burm-Jong |
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Institution: | Division of Marine Environment and Bioscience, Korea Maritime University, Busan 606-791, Korea. ywseo@hhu.ac.kr |
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Abstract: | Thunbergols A (4) and B (5), tetraprenyltoluquinols, along with three known compounds (1-3) have been isolated from the brown alga Sargassum thunbergii. The structures of these two new compounds were determined to be 9-(3,4-dihydro-2,8-dimethyl-6-hydroxy-2H-1-benzopyran-2-yl)-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-nonadienoic acid (4) and 10-(2,3-dihydro-5-hydroxy-7-methyl-1-benzofuran-2-yl)-10-hydroxy-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-undecadienoic acid (5), respectively, by combined spectroscopic methods. Both of them exhibited significant scavenging activities on radical and potently inhibited generation of ONOO(-) from morpholinosydnonimine (SIN-1). |
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