Graphene Nanocomposites Based Electrochemical Sensing Platform for Simultaneous Detection of Multi-drugs |
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Authors: | Tien Song Hiep Pham Shinichi Hasegawa Peter Mahon Katia Guérin Marc Dubois Aimin Yu |
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Institution: | 1. Department of Chemistry and Biotechnology, Swinburne University of Technology, VIC 3122 Melbourne, Australia;2. Institut de Chimie de Clermont-Ferrand, Université Blaise Pascal, F-63000 Clermont Ferrand, France |
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Abstract: | Three reduced graphene oxide nanocomposites were employed to achieve the simultaneous electrochemical determination of multi-drugs including acetaminophen (ACTM), carbendazim (CB) and ciprofloxacin (CFX). All nanocomposite modified electrodes showed improved current responses for three drugs. Notably cauliflower-like platinum nanoparticles decorated reduced graphene oxide modified electrode (or Pt−RGO/GCE) exhibited the best performance in terms of electrochemical stability. Using Pt−RGO/GCE, the linear detect ranges of 30–120 μM, 25–115 μM and 10–25 μM, and detection limit values of 3.49, 2.96, and 1.53 μM were achieved for ACTM, CB and CFX respectively. The electrode was further used for the successful determination of above drugs in tap and river water using differential pulse voltammetry. From the obtained results, we believe that Pt-RGO/GCE is highly promising for the fabrication of robust electrochemical sensors for simultaneously determining ACTM, CB and CFX or similar types of drugs in the future. |
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Keywords: | Electrochemical sensing Reduced graphene oxide Antibiotics measurement |
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