Electrochemiluminescence Single-cell Analysis on Nanostructured Interface |
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Authors: | Juanhua Zhou Shiyu Zhang Yang Liu |
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Institution: | Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Kay Lab of Bioorganic Phosphorus Chemistry and Chemical Biology of Ministry of Education, Tsinghua University, Beijing, 100084 China |
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Abstract: | Due to the heterogeneity of single cells, the development of single-cell analysis methods is conducive to the research of cellular mechanisms, clinical diagnosis, and treatment. Electrochemiluminescence (ECL) has the advantage of being controllable in time and space. Compared with spectroscopy, ECL does not require a light source, thus avoiding the interference of scattered light and luminescent impurities. Therefore, ECL is playing an increasingly important role in the field of single-cell analysis. In ECL single-cell analysis, it is important to construct a suitable nanostructure interface to realize signal conversion. This review first briefly introduced the ECL system commonly used in single-cell analysis, then focused on the recent developments in ECL single-cell analysis on nanostructure interface, finally discussed the future challenges and outlooks of ECL single-cell analysis. |
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Keywords: | electrochemiluminescence single-cell analysis nanostructured interface |
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