Development of a Diamond Nanoparticles-based Nanosensor for Detection and Determination of Antiviral Drug Favipiravir |
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Authors: | Çiğdem Kanbeş Dindar Burcin Bozal-Palabiyik Bengi Uslu |
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Institution: | Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560 Ankara, Turkey |
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Abstract: | This study developed a nanosensor for the detection and determination of favipiravir, a presumed drug that has potential therapeutic efficacy in treating COVID-19 patients, from tablets and serum samples. This nanosensor was obtained by adding the optimum amount of diamond nanoparticles into carbon paste. For the determination of favipiravir adsorptive stripping differential pulse (AdSDPV) and adsorptive stripping square wave voltammetry (AdSSWV) were used. Limit of detection values were found as 4.83×10−9 M and 2.44×10−7 M for bulk and 5.18×10−8 M and 4.38×10−8 M for serum samples using AdSDPV and AdSSWV, respectively. Recovery studies made of the tablet and serum produced satisfactory results. |
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Keywords: | Favipiravir diamond nanoparticles carbon paste electrode voltammetry validation |
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