Electrochemical Biosensors Based on Micro-fabricated Devices for Point-of-Care Testing: A Review |
| |
Authors: | Yuting Zhang Nandi Zhou |
| |
Institution: | The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122 China |
| |
Abstract: | Point-of-care testing (POCT) is becoming a hot research topic that allows rapid, on-site, and non-professional measurements outside the central laboratory. The micro-fabricated devices prepared by various micro-machining technologies have shown the advantages of low reagent consumption, high-throughput samples, and wearability. This review presents the recent progress of electrochemical biosensors based on various micro-fabricated devices for POCT and the corresponding electrochemical techniques. Signal amplification strategies based on enzyme and nanotechnology are also illustrated for the more sensitive POCT applications of these micro-fabricated devices. Consequently, the trends and challenges of electrochemical biosensors based on micro-fabricated devices in POCT diagnosis are discussed. |
| |
Keywords: | Point-of-care testing (POCT) Micro-fabricated devices Electroanalysis Biosensors Signal amplification |
|
|