Construction and Performance Characterization of Ion‐Selective Electrodes for Potentiometric Determination of Paroxetine Hydrochloride in Pharmaceutical Preparations and Biological Fluids |
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Authors: | Mohamed M Khalil Yousry M Issa Ali G Mohamed |
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Institution: | 1. Chemistry Department, Faculty of Science, Beni‐Suef University, Beni‐Suef, Egypt;2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt |
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Abstract: | Three types of ion‐selective electrodes: PVC membrane, modified carbon paste (CPE), and coated graphite electrodes (CGE) have been constructed for determining paroxetine hydrochloride (Prx). The electrodes are based on the ion pair of paroxetine with sodium tetraphenylborate (NaTPB) using dibutyl phthalate as plasticizing solvent. Fast, stable and potentiometric response was obtained over the concentration range of 1.1×10?5–1×10?2 mol L?1 with low detection limit of 6.9×10?6 mol L?1 and slope of a 56.7±0.3mV decade?1 for PVC membrane electrode, the concentration range of 2×10?5–1×10?2 mol L?1 with low detection limit of 1.2×10?5 mol L?1 and slope of a 57.7±0.6 mV decade?1 for CPE, and the concentration range of 2×10?5–1×10?2 mol L?1 with low detection limit of 8.9×10?6 mol L?1 and slope of a 56.1±0.1 mV decade?1 for CGE. The proposed electrodes display good selectivity for paroxetine with respect to a number of common inorganic and organic species. The electrodes were successfully applied to the potentiometric determination of paroxetine hydrochloride in its pure state, its pharmaceutical preparation, human urine and plasma. |
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Keywords: | Ion‐selective electrodes Potentiometry Paroxetine hydrochloride Biological fluids |
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