Electrical Properties of HeLa Cells Based on Scalable 3D Interdigital Electrode Array |
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| Authors: | Fu‐Yu Chang Ming‐Kun Chen Min‐Haw Wang Ling‐Sheng Jang |
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| Institution: | 1. Department of Electrical Engineering and Center for Micro/Nano Science and Technology, National Cheng Kung University, TAIWAN;2. Department of Electrical Engineering, Chinese Culture University, TAIWAN |
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| Abstract: | This study analyzed the electrical properties of a multiple‐cells using the electric cell‐substrate impedance sensing, a scalable three‐dimensional electrode array and an equivalent circuit model (ECM). The experimental results validated the accuracy and validity of the extraction method for the ECM. The ECM simulation results using the electrical properties extracted by measuring 52 HeLa cells successfully forecasted the impedance magnitudes and phases for 15, 29, 78, and 98 HeLa cells. Comparing the ECM simulations and measurements, the maximum average errors in magnitude and phase were 3.06 % and 4.67 %, suggesting the number of HeLa cells can be classified by their electrical properties. |
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| Keywords: | multiple‐cell impedance biosensor (MCIB) equivalent circuit model (ECM) HeLa cells three‐dimensional electrode array (3D‐IDEA) |
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