Semiquantitative Analysis of Biological Materials by Inductively Coupled Plasma–Mass Spectrometry |
| |
Authors: | Dula Amarasiriwardena Steven F Durrant Alexandra Lásztity Antoaneta Kvska Mark D Argentine Ramon M Barnes |
| |
Institution: | aSchool of Natural Science, Hampshire College, Amherst, Massachusetts, 01002;bDepartment of Chemistry, Lederle Graduate Research Center, University of Massachusetts, Box 34510, Amherst, Massachusetts, 01003-4510 |
| |
Abstract: | Semiquantitative analysis with accuracy of ±30 to 50% is a valuable tool for rapid screening of samples prior to quantitative determination of trace metals. In this study semiquantitative analysis software available with commercial inductively coupled plasma–mass spectrometry (ICP-MS) instrumentation is applied for rapid multielemental analysis, and the accuracy and precision of this semiquantitative analysis approach is evaluated with biological certified reference materials. Samples were prepared by high-pressure, high-temperature nitric acid vapor-phase digestion. For most elements the measured semiquantitative results are in the range of the certified values. With appropriate analyte solution dilution, the measured concentrations of the major elements (e.g., Ca) also agree with certified values. The accuracy is within ±10% for 28 element determinations that include 16 individual elements (Ag, As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Rb, Sb, Sr, Tl, and Zn) and ±20% for 54 element determinations that include three more elements (Mg, V, and U) in eight certified reference materials including water. The method precision is 11 ± 11% (relative standard deviation,n= 65). |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|