Preparation and properties of polyvinyl acetal sponge modified by chitosan |
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Authors: | Zhidan Lin Xiuju Zhang Rong Zeng |
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Institution: | (1) College of Science and Engineering, Jinan University, Guangzhou, 510632, China |
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Abstract: | The polyvinyl acetal sponge modified by chitosan was prepared by adding chitosan/polyvinyl alcohol (PVA) solution during the
acetalation reaction of PVA and formaldehyde. The effect of vesicant and chitosan to the pore morphology, water absorption
ratio, water absorption rate, expansion time and mechanical properties were studied. The polyvinyl acetal sponge modified
by chitosan was used as a hemostatic packing material for the injured rabbit nasal tissue. The hemostatic effect and the healing
effect of the modified sponge on the nasal mucosa after nasal surgery were studied. The results indicated that the polyvinyl
acetal sponge modified by chitosan has an interconnected pore structure and the wall between large pores also has small pores.
The chitosan adhered on the inner surface of the pores. The increased content of vesicant led to an increase in pore diameter,
in the water absorption ratio and in expansion time. However, there was only a small change in the water absorption rate and
a decrease in tensile strength and compression strength were noted. With an increase in chitosan content, the pore diameter
and interconnection of the sponge was reduced. Water absorption ratio, expansion time and water absorption rate decreased,
but tensile strength and compression strength improved. Observation of the rabbit nasal tissue after surgical operation suggested
that polyvinyl acetal sponge modified by chitosan has an anti-inflammatory, hemostatic and anti-adherent characteristic and
could promote the healing and functional recovery of rabbit nasal mucosa.
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Translated from Journal of Jinan University (Natural Science & Medicine Edition), 2007, 28(3): 283–287 译自: 暨南大学学报(自然科学与医学版)] |
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Keywords: | chitosan polyvinyl alcohol hemostatic sponge acetalation |
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