Biomimetic strengthening polylactide scaffold materials for bone tissue engineering |
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| Authors: | Guofu Xu Shenzhou Mou Zhimin Yin Lingping Zhou Fuzhai Cui Susan Liao |
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| Institution: | (1) School of Materials Science and Engineering, Central South University, Changsha, 410083, China;(2) College of Materials Science and Engineering, Hunan University, Changsha, 410082, China;(3) Department of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China;(4) National University of Singapore, Singapore, 117576, Singapore |
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| Abstract: | In this paper, a new polylactide (PLA)-based scaffold composite by biomimetic synthesis was designed. The novel composite
mainly consists of nano-hydroxyapatite (n-HA), which is the main inorganic content in natural bone tissue for the PLA. The crystal degree of the n-HA in the composite is low and the crystal size is very small, which is similar to that of natural bone. The compressive
strength of the composite is higher than that of the PLA scaffold. Using the osteoblast culture technique, we detected cell
behaviors on the biomaterial in vitro by SEM, and the cell affinity of the composite was found to be higher than that of the
PLA scaffold. The biomimetic three-dimensional porous composite can serve as a kind of excellent scaffold material for bone
tissue engineering because of its microstructure and properties.
Translated from Journal of Hunan University (Natural Sciences), 2006, 33(2) (in Chinese) |
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| Keywords: | hydroxyapatite bone tissue engineering PLA-based scaffold materials |
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