以N-乙烯基吡咯烷酮为功能单体的S-萘普生印迹聚合物材料的合成及性能研究

以S-萘普生为模板，N-乙烯基吡咯烷酮为功能单体，二乙烯基苯为交联剂分别按照摩尔比1／4／10、1／4／20和1／4／30合成了分子印迹聚合物(MIP)。采用UV和Chem 3D Pro软件计算模拟研究了功能单体与模板分子之间的相互作用，经半经验量化PM3方法计算得到功能单体与模板分子之间的相互作用能为-20．97 kJ／mol。探讨了交联度对MIP吸附性能和识别能力的影响，结果表明在所研究的O～4mmol／L浓度范围内，MIP对S-萘普生的结合量随着交联度的增加而减小，而交联度为88％的印迹聚合物P3对S-萘普生和阿司匹林的分离因子为2．70，交联度为83％的聚合物P2的分离因子为2．60，交联度为71％的聚合物P1的分离因子为1.44，即高交联度MIP的识别能力优于低交联度的。

Study on the Synthesis and Properties of S -Naproxen Molecularly Imprinted Polymers Using N-vinylpyrrolidone as a Functional Monomer

Molecularly imprinted polymers were prepared using S-naproxen as a template molecule, N-vinylpyrrolidone as a functional monomer and divinylbenzene as a crosslinker. By means of UV spectroscopy and computational approach, the interaction between template molecule and functional monomer was studied. The binding energy of the pre-polymerization was calculated by the use of PM3 method, which is -20.97 kJ/mol. The binding capacity of polymers revealed from adsorption isotherms decrease with the degree of cross-linking, whereas the experiments of selectivity show that the recognition properties of polymers increase with the degree of cross-linking.