| 阿司匹林-蒙脱土-壳聚糖缓释微球的制备及其体外释放性能 |
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| 引用本文： | 杨凤,赵伟,张欠.阿司匹林-蒙脱土-壳聚糖缓释微球的制备及其体外释放性能[J].功能高分子学报,2010,23(1). |
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| 作者姓名： | 杨凤 赵伟 张欠 |
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| 作者单位： | 沈阳化工学院材料科学与工程学院,沈阳,110142 |
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| 摘 要： | 利用溶液法预先制备壳聚糖(Cs)-蒙脱土(MMT)复合材料(Cs-MMT),以Cs-MMT、Cs为原料,采用反相悬浮聚合法制得一种新型药物缓释体系阿司匹林-蒙脱土-壳聚糖载药微球(Asp-MMT-Cs)。采用FT-IR、SEM表征了Cs-MMT和Asp-MMT-Cs载药微球的结构及形态;设计正交实验优化了Asp-MMT-Cs载药微球的制备工艺;通过体外释放实验探讨了载药微球在不同模拟释放液中的释药规律。结果表明:所得微球球形度好,粒径分布较均匀;最优工艺制得的载药微球平均粒径为81.20μm,载药量为9.61%,包封率为76.78%。该缓释体系具有pH敏感性,更倾向于在pH较高的磷酸盐缓冲溶液中释放。
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| 关 键 词： | 蒙脱土 壳聚糖 阿司匹林 载药微球 药物缓释 |
Preparation and in vitro Releasing Property of Aspirin-Montmorillonite-Chitosan Sustained-Release Microsphere |
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| YANG Feng,ZHAO Wei,ZHANG Qian.Preparation and in vitro Releasing Property of Aspirin-Montmorillonite-Chitosan Sustained-Release Microsphere[J].Journal of Functional Polymers,2010,23(1). |
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| Authors: | YANG Feng ZHAO Wei ZHANG Qian |
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| Institution: | School of Materials Science and Engineering;Shenyang Institute of Chemical Technology;Shenyang 110142;China |
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| Abstract: | Cs-MMT composites were prepared by solution method,and a new drug sustained-release system,Asp-MMT-Cs microspheres were synthesized by inverse suspension polymerization.FT-IR and SEM were applied to characterize the structure and morphology of the obtained Cs-MMT composites and Asp-MMT-Cs microspheres.Orthogonal experiment was designed to optimize the preparation process of the Asp-MMT-Cs microspheres.And in vitro release experiments were used to determine the release law of the sustained-release system.Res... |
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| Keywords: | montmorillonite chitosan aspirin microspheres drug release |
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