| 药用缓释辅料——羟丙基甲基纤维素的合成及其缓释性能的研究 |
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| 引用本文： | 张宪康,姜传渔,邬方涛,茅蕾芳,谢华达,郑斯骥.药用缓释辅料——羟丙基甲基纤维素的合成及其缓释性能的研究[J].功能高分子学报,1991(4). |
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| 作者姓名： | 张宪康 姜传渔 邬方涛 茅蕾芳 谢华达 郑斯骥 |
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| 作者单位： | 上海科技大学，上海科技大学，上海科技大学，上海医用合成材料厂，华东医院，延安制药厂 八三届毕业生 |
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| 摘 要： | 本文研究了药物缓释材料HPMC的合成方法,探讨了碱纤维素制备,醚化剂浓度,混合醚化剂配经以及产品后处理对高粘度HPMC的影响。本文还初步对KCl,氨茶碱,硝酸异山梨醇酯等药物采用合成的HPMC作辅料,进行了缓释制剂的研究,结果表明合成的HPMC具有满意的缓释性能。
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| 关 键 词： | 药用辅料 缓释放 羟丙基甲基纤维素 碱纤维素 醚化剂 |
A Study on the Supplement of Medicine Hydroxpropyl Methylcellulose and it's Properties of Control Release |
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| Zhang Xiankang Jiang Chuanyu Wu Fangtao.A Study on the Supplement of Medicine Hydroxpropyl Methylcellulose and it''''s Properties of Control Release[J].Journal of Functional Polymers,1991(4). |
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| Authors: | Zhang Xiankang Jiang Chuanyu Wu Fangtao |
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| Abstract: | The high viscosity HPMC was prepared as the supplements of medicine. The factors of synthesis, for example alkali cellulose, concentration and ratio of the mixed etherifying agents, and product aftertreatment were studied. The control release of medicine, as potassium chloride, aminophyllinum isosorbidi dinitras (sorbide nitrate), were also investigated. The satisfied properties of control release of the high viscosity HPMC were showed. |
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| Keywords: | supplement of medicine control release hydroxypropyl methycellulose alkali cellulose mixed etherifying agent |
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