| 同轴电喷法制备PCL-蛋清体系复合微胶囊 |
| |
| 引用本文： | 余松林,俞昊,功靓,朱美芳,陈彦模.同轴电喷法制备PCL-蛋清体系复合微胶囊[J].功能高分子学报,2011,24(1). |
| |
| 作者姓名： | 余松林 俞昊 功靓 朱美芳 陈彦模 |
| |
| 作者单位： | 余松林,俞昊,功靓,YU Song-lin,YU Hao,GONG Liang(东华大学材料科学与工程学院,上海,201620);朱美芳,陈彦模,ZHU Mei-fang,CHEN Yan-mo(东华大学纤维材料改性国家重点实验,上海,201620) |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 以鸡蛋的卵清蛋白作为蛋白质药物模板、生物可降解材料聚己内酯(PCL)为药物载体模板,采用同轴电喷法制备PCL-蛋清体系的复合微球.研究了电导率、黏度对于电喷微球成型的影响.核壳溶液推进速率比、电压、溶液质量分数和接收距离等对于所得微球表面形态和结构的影响.利用扫描电子显微镜(SEM)研究了微球的表面形态,用荧光显微镜表征了微球的包覆模式.结果表明:同轴电喷法可以制备PCL-蛋清体系的复合结构微胶囊,其中推进速率比对微球形貌、粒径及其分布的影响比较明显,当PCL与蛋清溶液推进速率比大于10时,将出现具有包覆结构的微球.
|
| 关 键 词： | 同轴电喷 复合微球 药物缓释 蛋清 聚己内酯 |
Production of PCL-Egg White Composite Microcapsule by Coaxial Electrospraying |
| |
| YU Song-lin,YU Hao,GONG Liang,ZHU Mei-fang,CHEN Yan-mo.Production of PCL-Egg White Composite Microcapsule by Coaxial Electrospraying[J].Journal of Functional Polymers,2011,24(1). |
| |
| Authors: | YU Song-lin YU Hao GONG Liang ZHU Mei-fang CHEN Yan-mo |
| |
| Institution: | YU Song-lin,YU Hao~(1),GONG Liang~1,ZHU Mei-fang~2,CHEN Yan-mo~2(1.College of Materials Science and Engineering,2.State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China) |
| |
| Abstract: | The composite microcapsules of PCL(polycaprolactone)-egg white were prepared via coaxial electrospraying.Egg white and PCL were used as the templates of protein drugs and drug carrier,respectively.The influence of solution properties,such as the conductivity and viscosity,to the final structure of the microspheres were investigated,as well as the influence of the operation parameters,including the(ratio) of the two liquid flow rates,voltage,collecting distance,etc,to the morphology of the microspheres.The p... |
| |
| Keywords: | coaxial electrospraying composite microcapsule controlled drug release egg white PCL |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
