| 主链含氨基酸、5-氟尿嘧啶、氮芥的聚磷酰胺和聚磷酸酯的合成及其抗肿瘤活性研究 |
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| 引用本文： | 赵儒林,范昌烈,卓仁禧.主链含氨基酸、5-氟尿嘧啶、氮芥的聚磷酰胺和聚磷酸酯的合成及其抗肿瘤活性研究[J].功能高分子学报,1989(4). |
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| 作者姓名： | 赵儒林 范昌烈 卓仁禧 |
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| 作者单位： | 武汉大学化学系
(赵儒林，范昌烈)，武汉大学化学系(卓仁禧) |
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| 摘 要： | 由1,3-双(氨基酸丙酯盐酸盐)-5-氟尿嘧啶与双(2-氯乙基)氨基磷酰二氯在DMF中反应得到十种含氨基酸、氮芥和5-氟尿嘧啶啶三组分的聚合物。通过核磁、红外和紫外以及元素分析测定了聚合物的结构。试验了聚合物的体外抗肿瘤活性。
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Synthesis and Antitumor Activity of Polyphosphoramides and Polyphosphates Containing Amino Acid,5-Fluorouracil and Nitrogen Mustard |
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| Zhao Rulin,Fan Changlie,Zhuo Renxi.Synthesis and Antitumor Activity of Polyphosphoramides and Polyphosphates Containing Amino Acid,5-Fluorouracil and Nitrogen Mustard[J].Journal of Functional Polymers,1989(4). |
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| Authors: | Zhao Rulin Fan Changlie Zhuo Renxi |
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| Institution: | Zhao Rulin,Fan Changlie,Zhuo Renxi Department of Chemistry,Wuhan University,Wuhan |
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| Abstract: | By the polycondensation of amino acid 5--fluorouracil--1,3--dipropyl esters withbis (2--chloroethyl)--phosphoramidic dichloride in the presence of Et_3N orin Vacuo, tennew polymers containing 5--fluorouracil, nitrogen mustard and amino acid weresynthesized. The polymers were structurally characterized by ~1H NMR, UV, IR andelemental analysis. The antitumor activity of all of the polymers were tested againstEAC in vitro, the preliminary results indicate that some of the polymers exhibit certainantitumor activity. |
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| Keywords: | Amino acid Nitrogen mustard 5-fluorouracil polymer Antitumor activity |
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