| 聚氯乙烯表面共价键合肝素及抗凝血性的研究 |
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| 引用本文： | 刘鹏,陈亚芍,张丽惠.聚氯乙烯表面共价键合肝素及抗凝血性的研究[J].功能高分子学报,2004,17(1):35-40. |
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| 作者姓名： | 刘鹏 陈亚芍 张丽惠 |
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| 作者单位： | 陕西师范大学化学与材料科学学院,陕西,西安,710062;陕西师范大学化学与材料科学学院,陕西,西安,710062;陕西师范大学化学与材料科学学院,陕西,西安,710062 |
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| 基金项目： | 教育部留学回国人员科研启动基金资助项目(2001345)，陕西省自然科学基金资助项目(2001H18) |
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| 摘 要： | 采用Ar等离子体引发聚乙二醇(PEG)在聚氯乙烯(PVC)表面固定化，进一步对固定PEG后的PVC进行肝素化处理，以改善PVC材料的抗凝血性能。探讨了PEG浓度对Ar等离子体固定化反应效果的影响。通过X射线光电子能谱(XPS)、衰减全反射红外光谱(ATR-FTIR)、扫描电镜(SEM)和接触角测定研究了固定PEG前后PVC的表面性能和表面形貌的变化。XPS分析证实肝素已成功地共价键合于PVC表面。采用体外凝血时间测定和血小板粘附实验对材料的抗凝血性能进行评价，结果表明，被修饰PVC材料的抗凝血性能显著提高。
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| 关 键 词： | 等离子体 聚氯乙烯 肝素 抗凝血性 |
| 文章编号： | 1008-9357(2004)01-0035-06 |
| 修稿时间： | 2003年8月29日 |
Study of Covalent Immobilization of Heparin onto the Surface of Poly(vinyl chloride) for Antithrombogenicity |
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| LIU Peng,CHEN Ya-shao,ZHANG Li-hui.Study of Covalent Immobilization of Heparin onto the Surface of Poly(vinyl chloride) for Antithrombogenicity[J].Journal of Functional Polymers,2004,17(1):35-40. |
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| Authors: | LIU Peng CHEN Ya-shao ZHANG Li-hui |
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| Abstract: | Poly(ethylene glycol) (PEG) was immobilized onto the surface of Poly(vinyl chloride) (PVC) by the argon plasma-induced reaction, followed by a reaction with heparin to improve the antithrombogenicity of PVC. The effect of PEG concentration on immobilizing reaction by Ar plasma was investigated. The surface properties and morphologies of PVC before and after immobilizing PEG were studied by XPS, ATR-FTIR, SEM and contact angle. It is confirmed that heparin was covalently immobilized onto surface of PVC. The antithrombogenicity was determined by clotting time measurement in vitro and platelet adhesion experiment. It is shown that the antithrombogenicity of modified PVC materials is increased greatly. |
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| Keywords: | plasma poly(vinyl chloride) heparin antithrombogenicity |
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