Determination of the conformations and relative configurations of exocyclic amines |
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Authors: | Montalvo-González J Ascención Iniestra-Galindo María Guadalupe Ariza-Castolo Armando |
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Institution: | Departamento de Química, Cinvestav, Av. IPN 2508, Zacatenco, Mexico. |
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Abstract: | The conformations and relative configurations of 20 amines, classified according to the following labeling scheme, were analyzed. Series a comprised compounds derived from N-(1-phenylethyl)cyclohexanamine, b comprised derivatives of N-1-(naphthalen-2-yl)ethyl]cyclohexanamine, c comprised derivatives of N-(diphenylmethyl)cyclohexanamine, and d comprised derivatives of N-(propan-2-yl)cyclohexanamine. The compounds were labeled as follows: 1 indicates cyclohexanamine, 2 indicates 2-methylcyclohexanamines, 3 indicates 3-methylcyclohexanamines, 4 indicates 4-methylcyclohexanamines, and 5 indicates 4-tert-butylcyclohexanamines. These compounds were prepared without the use of stereoselective induction and, therefore, all expected stereoisomers were observed. Structural assignments were established by (1)H, (13)C, and (15)N NMR. |
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Keywords: | 1H 13C and 15N NMR conformation configuration exocyclic amine |
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