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NMR and conformational studies of new 5‐phenylpyrrole‐carboxamide derivatives |
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| Authors: | Luisa C López‐Cara M José Pineda de las Infantas M Dora Carrión M Encarnación Camacho Miguel A Gallo Antonio Espinosa Antonio Entrena |
| Institution: | Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain |
| Abstract: | The 1H and 13C NMR resonances of 22 5‐(5‐substituted‐2‐nitrophenyl)‐1H‐pyrrole‐2‐carboxamides, 22 5‐(5‐substituted‐2‐aminophenyl)‐1H‐pyrrole‐2‐carboxamides, and 9 5‐phenyl‐1H‐pyrrole‐2‐carboxamides were assigned completely using the concerted application of one‐ and two‐dimensional experiments (DEPT, gs‐HMQC and gs‐HMBC). NOE studies and conformational analysis confirm the preferred conformations of such compounds. Copyright © 2009 John Wiley & Sons, Ltd. |
| Keywords: | NMR 1H 13C HMQC HMBC NOEDIFF 5‐phenyl‐1H‐pyrrole‐2‐carboxamides |