Enantioselective total synthesis and absolute configuration of apiosporic acid |
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| Authors: | Gärtner Martin Kossler David Pflästerer Daniel Helmchen Günter |
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| Institution: | Organisch-Chemisches Institut der Ruprecht-Karls-Universit?t Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany. |
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| Abstract: | The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined. |
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