Reactivity of 2-deoxy-2-iodoglycosyl isothiocyanates with O-, S-, and N-nucleophiles. Synthesis of glycopyranoso-fused thiazoles |
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Authors: | Isac-García Joaquin Hernández-Mateo Fernando Calvo-Flores Francisco G Santoyo-González Francisco |
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Institution: | Instituto de Biotecnología. Departamento de Química Orgánica, Facultad de Ciencias, Campus Fuentenueva s/n, Universidad de Granada, Granada, E-18071, Spain. |
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Abstract: | The reactivity of 2-deoxy-2-iodoglycosyl isothiocyanates toward O- and S-nucleophiles gives an easy access to 2-deoxy-2-iodoglycopyranosyl thiocarbamates and dithiocarbamates. Internal nucleophilic displacement of the iodine by the sulfur atom in these compounds allows the preparation of glycopyranoso1,2-d]-1,3-thiazoles and glycopyranoso1,2-d]-1,3-thiazolidin-2-one or -2-thione. Reaction with amines or polyamines as N-nucleophiles led directly to 2-aminoglycopyranoso1,2-d]-1,3-thiazoles without isolation of the intermediate thioureas. Methyl 2-deoxy-2-iodoglycopyranosyl thiocarbamates also allow the synthesis of 2-deoxyglycopyranosyl thiocarbamates or 2-deoxy-2-iodoglycopyranosyl carbamates. |
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