Concise total synthesis of (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine |
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Authors: | Yamauchi Takayasu Hagiwara Sachi Higashiyama Kimio |
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Institution: | Institute of Medicinal Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142-8501, Japan. yamauchi@hoshi.ac.jp |
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Abstract: | The concise enantioselective total synthesis of C(2)-asymmetrical (-)-deoxocuscohygrine and (-)-dihydrocuscohygrine are described. Double-diastereoselective additions of normal Grignard reagent to bis(1,3-oxazolidine) have been deployed to construct chiral diamine fragments as a key step. |
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