Ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation of 1,4-diols: synthesis of gamma-hydroxy ketones |
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| Authors: | Martín-Matute Belén Bäckvall Jan-E |
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| Institution: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden. |
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| Abstract: | Enzymatic kinetic resolution of unsymmetrical 1,4-diols in combination with a ruthenium-catalyzed hydrogen transfer process led to a dynamic kinetic asymmetric transformation (DYKAT) of the least hindered alcohol. Oxidation of the second hydroxy group takes place under the reaction conditions leading to the formation of gamma-acetoxy ketones in high enantiomeric purity. |
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