Spectrophotometric Determination of Metoclopramide in Pharmaceutical Preparations

A simple and rapid spectrophotometric method for the determination of metoclopramide is described. The method is based upon simple diazotization reactions with nitrite and aniline as the coupling reagent. The absorbance was measured at 410 nm. The method was optimized for acidity, the amount of reagents required, and the amount of sodium hydroxide. The range of linearity was 0.5–12.0 µg/mL. The method was successfully applied to the determination of metoclopramide in pharmaceutical preparations without any interference from common excipients.__________From Zhurnal Analiticheskoi Khimii, Vol. 60, No. 7, 2005, pp. 711–714.Original English Text Copyright © 2005 by Shah, Rasul Jan, Azam Khan, Amin.The text was submitted by the authors in English.