Hydroxy- and alkoxymethylation of polyfluoroalkyl pyrazoles |
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| Authors: | А Е Ivanova E V Shchegol´kov Ya V Burgart V I Saloutin |
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| Institution: | 1.Postovsky Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences,Ekaterinburg,Russian Federation |
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| Abstract: | A synthetic route to 1-hydroxy- and 1-alkoxymethyl-3-polyfluoroalkylpyrazoles via regioselective N-hydroxy- and alkoxymethylation of N-unsubstituted pyrazoles with paraformaldehyde has been proposed. The alkoxyalkylation of polyfluoroalkylpyrazoles proceeds in aqueous-alcohol medium, whereas hydroxymethylation requires anhydrous conditions. |
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