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Design,synthesis and evaluation of the antioxidant and neuroprotective properties of alkyl- and terpenylphenolchlorin conjugates |
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| Authors: | Chukicheva I Yu Buravlev E V Belykh D V Khudyaeva I S Fedorova I V Shevchenko O G Maximova M A Zainullina L F Vakhitova Yu V Kutchin A V |
| Institution: | 1.Institute of Chemistry, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomayskaya, 167000, Syktyvkar, Russian Federation ;2.Institute of Biology, Komi Scientific Centre, Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation ;3.Institute of Biochemistry and Genetics, Ufa Scientific Centre of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation ;4.V. V. Zakusov Institute of Pharmacology, 8 ul. Baltiyskaya, 125315, Moscow, Russian Federation ; |
| Abstract: | The new amide conjugates were synthesized from methyl pheophorbide a and its carboxyl derivatives by reactions with aminomethyl derivatives of 2,4-dimethylphenol, 2-isocamphyl-4- methylphenol, 2-bornyl-4-methylphenol, and 2-isobornyl-4-methylphenol. The antioxidant activity of some conjugates was established by investigation of their ability to inhibit the accumulation of secondary products of lipid peroxidation in a brain of laboratory mice in vitro. The neuroprotective properties of porphyrin and terpenylphenol conjugates have been studied on the model of H2O2-induced oxidative stress in SH-SY5Y cells (neuroblastoma). |
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