Polyfused nitrogen-containing heterocycles 18. 2′-Amino-5-methyl-1,2,3,4,4′,5′-hexahydrospiro[quinoxaline-2,4′-thiazol]-3-ones. Synthesis,structure, and recyclization

Bis-3-(α-bromoethyl)quinoxalin-2-ones with 3-oxapentane or 3,6-dioxaoctane spacer binding two heterocyclic fragments react with thiourea to give the corresponding bis-spirothiazoloquinoxalines, which upon treatment with acetic anhydride can be converted to podands with terminal thiazoloannulated quinoxaline fragments. X-Ray data for 2′-amino-4-ethyl-5-methyl-1,2,3,4,4′,5′-hexahydrospiroquinoxaline-2,4′-thiazol]-3-one indicate for this compound a potentiality to form clathrate structures with various solvate molecules. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2386–2393, December, 2007.