| Interactions between Bioactive Diperoxovanadate Complexes and Imidazole： Insights into Their Solution Structures by NMR and ESI-MS |
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| 引用本文： | 于贤勇,蔡淑惠,陈忠.Interactions between Bioactive Diperoxovanadate Complexes and Imidazole： Insights into Their Solution Structures by NMR and ESI-MS[J].结构化学,2004,23(6):511-518. |
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| 作者姓名： | 于贤勇 蔡淑惠 陈忠 |
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| 作者单位： | YU Xian-Yong CAI Shu-Hui CHEN Zhong② (Departments of Physics and Chemistry，State Key Laboratory for Physical Chemistry of Solid Surface，Xiamen University，Xiamen 361005，China) (State Key Laboratory of Structural Chemistry，Fuzhou 350002，China) |
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| 基金项目： | NNSFC (Nos. 10234070 and 10104011)，NSF of Fujian Province (No. E0110003) and State Key Laboratory of Structural Chemistry (020058) |
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| 摘 要： | 1 INTRODUCTION As a required metal for some enzymes such as haloperidases and nitrogenases, vanadium com- pounds are capable of having many biological acti- vities. Similar to inorganic phosphates, vanadium compounds activate the functions of a numb…
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| 关 键 词： | 交互作用 咪唑 过氧化钒酸盐 生物活性 核磁共振 ESI-MS NMR 竞争吸附作用 结构 |
Interactions between Bioactive Diperoxovanadate Complexes and Imidazole:Insights into Their Solution Structures by NMR and ESI-MS |
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| YU Xian-Yong,CAI Shu-hui,CHEN Zhong.Interactions between Bioactive Diperoxovanadate Complexes and Imidazole:Insights into Their Solution Structures by NMR and ESI-MS[J].Chinese Journal of Structural Chemistry,2004,23(6):511-518. |
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| Authors: | YU Xian-Yong CAI Shu-hui CHEN Zhong |
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| Institution: | Departments of Physics and Chemistry, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, China;State Key Laboratory of Structural Chemistry, Fuzhou 350002, China;Departments of Physics and Chemistry, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, China;State Key Laboratory of Structural Chemistry, Fuzhou 350002, China;Departments of Physics and Chemistry, State Key Laboratory for Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, China;State Key Laboratory of Structural Chemistry, Fuzhou 350002, China |
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| Abstract: | The interactions between four high bioactive diperoxovanadate complexes KnOV(O2)2L]mH2O (n = 1~3, m = 1~5, L = oxalate (abbr. oxa), picolinate (abbr. pic), bipyridine (abbr. bipy) and 1,10-phenanthroline (abbr. phen); their corresponding complexes abbreviated as bpV(oxa), bpV(pic), bpV(bipy) and bpV(phen), respectively) and imidazole (abbr. imi) in solution were studied by several NMR techniques: multinuclear (1H, 13C and 51V) and variable temperature 51V NMR. Competitive coordination interactions were observed and the order of the interaction strength of the four complexes with imidazole is as follows: bpV(oxa) > bpV(pic) > bpV(bipy) > bpV(phen), which is deeply affected by the identity of the ligands and has the same order as their inhibition effect toward bovine heart phosphotyrosyl protein phosphatase. The species OV- (O2)2(imi)]- was formed in all cases. Both of the NMR data and equilibrium constants of the interaction systems were reported. The experimental results indicate that the species of bpV(oxa) and OV(O2)2(imi)]- are six-coordinated, while bpV(pic), bpV(bipy) and bpV(phen) are seven- coordinated in solution. ESI-MS results support the conclusions obtained by NMR. |
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| Keywords: | diperoxovanadate imidazole interaction NMR ESI-MS |
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