| Synthesis and Crystal Structure of N-Hydroxy-9-(3’,4’-methylene- dioxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9, 10-decahydroacridine in Aqueous Media |
| |
| 引用本文： | 史达清,牟杰,庄启亚,王香善.Synthesis and Crystal Structure of N-Hydroxy-9-(3’,4’-methylene- dioxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9, 10-decahydroacridine in Aqueous Media[J].结构化学,2005(9). |
| |
| 作者姓名： | 史达清 牟杰 庄启亚 王香善 |
| |
| 作者单位： | Department of Chemistry，Xuzhou Normal University，Xuzhou 221116，ChinaKey Laboratory of Biotechnology on Medical Plants of Jiangsu Province，Xuzhou 221116，China，Department of Chemistry，Xuzhou Normal University，Xuzhou 221116，China，Department of Chemistry，Xuzhou Normal University，Xuzhou 221116，ChinaKey Laboratory of Biotechnology on Medical Plants of Jiangsu Province，Xuzhou 221116，China，Department of Chemistry，Xuzhou Normal University，Xuzhou 221116，ChinaKey Laboratory of Biotechnology on Medical Plants of Jiangsu Province，Xuzhou 221116，China |
| |
| 基金项目： | This work was supported by the Foundation of “Innovation Project” of Xuzhou Normal University |
| |
| 摘 要： | 1 INTRODUCTION Acridine derivatives are described to have many applications, such as biological fluorescent probes1] as well as anti-tumor2], anti-bacterial3], anti-HIV4] and anti-malarial5] agents. Because of the importance of acridine derivatives, much work has been done for several decades. Among them the classical synthetic methods involve condensing functionalized anilines and o-halogeno- benzoic acid derivatives as well as several other steps resulting in the desired acridine…
|
Synthesis and Crystal Structureof N-Hydroxy-9-(3′,4′-methylene-dioxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine in Aqueous Media |
| |
| Abstract: | The title compound N-hydroxy-9-(3′,4′-methylenedioxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine (C20H19NO5, Mr = 353.36) is of orthorhombic, space group Pna21 with a = 14.6914(16), b = 8.8103(10), c = 12.6648(14) , Z = 4, V = 1639.3(3) 3, Dc = 1.432 g/cm3, ((MoK() = 0.103 mm-1, F(000) = 744, R = 0.0445 and wR = 0.1043 for 2172 observed reflections (I > 2((I)). X-ray analysis reveals that the pyridine and cyclohexane rings adopt boat and half-chair configurations, respectively. In addition, there is an intermolecular hydrogen bond (O(1)-H...O(3)) in the title molecule. |
| |
| Keywords: | crystal structure N-hydroxylacridine green chemistry |
| 本文献已被 CNKI 等数据库收录！ |
|
