| Synthesis and Crystal Structure of (9S)-2′-O-Benzoyl-9,11-[carbonylbis(oxy)]-9-deoxo-5-O-(β-D-desosaminyl)-12,21-anhydro-9-hydroxy-erythronolide A |
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| 引用本文： | 王永涛,陈卫民,胡艾希,江仁望,曹高,苏文魁,关东.Synthesis and Crystal Structure of (9S)-2′-O-Benzoyl-9,11-[carbonylbis(oxy)]-9-deoxo-5-O-(β-D-desosaminyl)-12,21-anhydro-9-hydroxy-erythronolide A[J].结构化学,2009(2). |
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| 作者姓名： | 王永涛 陈卫民 胡艾希 江仁望 曹高 苏文魁 关东 |
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| 作者单位： | College;Chemistry;Chemical;Engineering;Hunan;University;Changsha;410082;China;Guangdong;Provincial;Laboratory;Pharmacodynamic;Constituents;Drugs;Research;Pharmacy;Jinan;Guangzhou;510632; |
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| 基金项目： | supported by the Natural Science Foundation of Guangdong Province (No. 06025150) |
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| 摘 要： | The title compound (9S)-2′-O-benzoyl-9,11-carbonylbis(oxy)]-9-deoxo-5-O-(-D-desosaminyl)-12,21-anhydro-9-hydroxyerythronolide A 1 was synthesized. The crystal structure of the acetone solvate of 1, C37H55NO11·C3H6O, was determined by single-crystal X-ray diffraction analysis. It belongs to monoclinic system, space group P21 with a = 14.4691(10), b = 8.2626(6), c = 17.5990(11) , β = 94.167(1)°, V = 2098.4(2)3, Mr = 748, Z = 2, Dc = 1.184 g/cm3, μ = 0.087 mm-1, F(000) = 808, S = 1.026, R = 0.0542 and wR = 0.1322 for 3331 observed reflections (I > 2σ(I)). In the solid state, molecules of 1 are linked into spirals along the b axis by O(25)- H(25)···O(29) intermolecular hydrogen bond.
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