| Biological Activities and Crystal Structure of the Natural Anti-cancer Drug: Cucurbitacin Ⅱa |
| |
| 摘 要： | We isolated cucurbitacin Ⅱa from the rhizomes of Hemsleya pengxianensis, and tested the cytotoxicity of cucurbitacin Ⅱa against various cancer cell lines by the sulforhodamine B assay(SRB). At the same time, we preliminarily found that cucurbitacin Ⅱa has a certain inhibitory activity on kinase CDK1/cyclin B, and shows potent inhibitory activities against many cancer cell lines. The cucurbitacin Ⅱa was structurally characterized by specific optical rotation measurement, high-resolution mass spectroscopy and NMR spectroscopic analysis. In addition, the molecular structure of cucurbitacin Ⅱa was further determined by X-ray single-crystal crystallography.
|
Biological Activities and Crystal Structure of the Natural Anti-cancer Drug: Cucurbitacin Ⅱa |
| |
| Institution: | School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;Institute of Materia Medica,Shandong First Medical University & Shandong Academy of Medical Sciences,Jinan 250062,China;Institute of Materia Medica,Shandong First Medical University & Shandong Academy of Medical Sciences,Jinan 250062,China |
| |
| Abstract: | |
| |
| Keywords: | |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
