Synthesis and Crystal Structure of 3,3‘—（Hexane—1,6—diyl）bis（1—acetyl—5,5—dimethylhydantoin）,a New Inducer of Differentiation Synthesis and Crystal Structure of 3,3'-(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin),a New Inducer of Differentiation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Synthesis and Crystal Structure of 3,3‘—（Hexane—1,6—diyl）bis（1—acetyl—5,5—dimethylhydantoin）,a New Inducer of Differentiation

作者单位：	State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Physical Chemistry, Peking University, Beijing 100871, China

摘要：
关键词：	HMBA 1 6－亚己基双乙酰胺癌细胞 C20H30N4O6 合成晶体结构生物活性
Synthesis and Crystal Structure of 3,3'-(Hexane-1,6-diyl)bis(1-acetyl-5,5-dimethylhydantoin),a New Inducer of Differentiation

Authors:	SONG Xiang-Zhi LIU Guang SHEN Li-Chun ZHANG Shi-Wei

Abstract:	The title compound C20H30N4O6, Mr = 422.48)was synthesized and its crystal structure was determined by X-ray diffraction method. It crystallizes in the triclinic system, space group P ī with cell parameters: a = 8.330(2), b = 8.468(2), c = 16.017(3) A, α = 97.30(3), β = 92.33(3), γ = 103.94(3)o, V = 1084.7(4) A3, Dc = 1.294 g/cm3, Z = 2, F(000) = 452 and μ = 0.096 mm-1. The structure was refined to R = 0.0483 for 3732 observed reflections with I>2(I) and wR = 0.1335 for 4828 unique reflections. The hydantoin rings are planar and the two ring planes of one molecule are paralleled to each other.

Keywords:	HMBA anticancer activity cancer cell inducer of differentiation crystal structure
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