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| Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra（trifluoroethoxy） Germanium Phthalocyanine① | |
| 引用本文： | 吴丽荣,黄丽英,林振华.Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra（trifluoroethoxy） Germanium Phthalocyanine①[J].结构化学,2014,33(7):1081-1090. |
| 作者姓名： | 吴丽荣 黄丽英 林振华 |
| 作者单位： | [1]College of Pharmacy, Fujian Medical University, Fuzhou 350004, China; [2]Quanzhou Medical College, Quanzhou 362010, China; [3]2nd Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China |
| 基金项目： | Supported by the Natural Science Foundation of Fujian Province(2012J01368) |
| 摘 要： | The synthesis and in vitro photodynamic anticancer activity of a new photosensitizer, tetra(trifluoroethoxy) germanium phthalocyanine(GePcF), were studied. GePcF was characterized by UV-Vis, IR, MS and elemental analysis. The in vitro photodynamic activity of GePcF was studied by MTT. IC50 of GePcF for SW480 cells of human colonic adenocarcinoma and HeLa cells of cervical cancer were 36.53 and 45.78 μmol/L, respectively. GePcF as a photosensitizer may be used to treat cancers due to its photodynamic anticancer activity. |
| 关 键 词： | 三氟乙氧基 抗癌活性 体外 酞菁 合成 HeLa细胞 锗 光动力活性 |
Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra(trifluoroethoxy) Germanium Phthalocyanine |
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| WU Li-Rong , HUANG Li-Ying , LIN Zhen-Hua.Study on the Synthesis and in vitro Photodynamic Anti-cancer Activity of Tetra(trifluoroethoxy) Germanium Phthalocyanine[J].Chinese Journal of Structural Chemistry,2014,33(7):1081-1090. | |
| Authors: | WU Li-Rong HUANG Li-Ying LIN Zhen-Hua |
| Institution: | 1. Quanzhou Medical College, Quanzhou 362010, China 2. College of Pharmacy, Fujian Medical University, Fuzhou 350004, China 3. 2nd Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China |
| Abstract: | tetra（trifluoroethoxy） germanium phthalocyanine, synthesis,characterization, photodynamic activity |
| Keywords: | tetra(trifluoroethoxy) germanium phthalocyanine synthesis characterization photodynamic activity |
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