| Synthesis,Crystal Structure and Anti-tumor Activity of 2-（2-Chloro-4-nitrophenyl）-4- （4-chlorophenyl）-3a,4-diethoxy-2,3,3a, 4-tetrahydrochromeno[3,4-d] [ 1,2,3]diazaphosphole |
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| 引用本文： | YING Hua-Zhou SUN Mao-Tang LIU Tao HU Yong-Zhou①.Synthesis,Crystal Structure and Anti-tumor Activity of 2-（2-Chloro-4-nitrophenyl）-4- （4-chlorophenyl）-3a,4-diethoxy-2,3,3a, 4-tetrahydrochromeno[3,4-d] [ 1,2,3]diazaphosphole[J].结构化学,2008,27(10):1171-1174. |
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| 作者姓名： | YING Hua-Zhou SUN Mao-Tang LIU Tao HU Yong-Zhou① |
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| 作者单位： | ZJU-ENS Joint Laboratory of Medicinal Chemistry，College of Pharmaceutical Science，Zhejiang University，Zijingang Campus |
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| 摘 要： | The title compound 2-（2-chloro-4-nitrophenyl）-4-（4-chlorophenyl）-3a,4- diethoxy- 2,3,3a, 4-tetrahydrochromeno3,4-d]1,2,3]diazaphosphole 2 （C29H30Cl2N3O7P, Mr = 633.44） was synthesized and its structure was characterized by IR, MS, ^1H NMR, ^13C NMR, ^31p NMR, elemental analysis and single-crystal X-ray diffraction. It crystallizes in triclinic, space group P1^-, a = 9.1549（3）, b = 10.7168（4）, c = 17.6272（6）A, α = 102.9363（12）, β = 90.2713（9）, γ = 117.4265（10）°, V= 1484.41（9）A^3, Z= 2,μ（MoKa） = 0.323, F（000） = 658, Z= 2, De= 1.417 g/cm^3, the final R = 0.0687 and wR = 0.2066 for 4943 observed reflections （I 〉 2σ（I））. X-ray analysis reveals that the diazaphospholine ring is almost planar and the two ethoxy groups bonded on the 3a- and 4-positions are in trans configurations. Its antiproliferative activity was also tested in vitro against four human tumor cell lines.
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| 关 键 词： | 2-(2-氯醛-4-硝基苯)-4-(4-氯苯酚)-3a 4-二乙基-2 3 3a 4-四氢柠檬醛 抗癌抗菌素 |
Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole |
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| YING Hua-Zhou,SUN Mao-Tang,LIU Tao,HU Yong-Zhou.Synthesis, Crystal Structure and Anti-tumor Activity of 2-(2-Chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4-diethoxy-2,3,3a,4-tetrahydrochromeno[3,4-d][1,2,3]diazaphosphole[J].Chinese Journal of Structural Chemistry,2008,27(10):1171-1174. |
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| Authors: | YING Hua-Zhou SUN Mao-Tang LIU Tao HU Yong-Zhou |
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| Institution: | ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Science, Zhejiang University, Zijingang Campus, Hangzhou 310058, China |
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| Abstract: | The title compound 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a,4- diethoxy- 2,3,3a,4-tetrahydrochromeno3,4-d]1,2,3]diazaphosphole 2 (C29H30Cl2N3O7P,Mr=633.44) was synthesized and its structure was characterized by IR,MS,1H NMR,13C NMR,31P NMR,elemental analysis and single-crystal X-ray diffraction. It crystallizes in triclinic,space group P1,a=9.1549(3),b=10.7168(4),c=17.6272(6),α=102.9363(12),β=90.2713(9),γ=117.4265(10)°,V=1484.41(9)3,Z=2,μ(MoKα)=0.323,F(000)=658,Z=2,Dc=1.417 g/cm3,the final R=0.0687 and wR=0.2066 for 4943 observed reflections (I > 2σ(I)). X-ray analysis reveals that the diazaphospholine ring is almost planar and the two ethoxy groups bonded on the 3a- and 4-positions are in trans configurations. Its antiproliferative activity was also tested in vitro against four human tumor cell lines. |
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| Keywords: | synthesis crystal structure 2-(2-chloro-4-nitrophenyl)-4-(4-chlorophenyl)-3a 4-diethoxy-2 3 3a 4-tetrahydrochromeno[3 4-d][1 2 3]diazaphosphole anti-tumor |
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