| Synthesis and Crystal Structure of （E）-2-phenyl-6,7dihydrobenzofuran-4（5H）-one O-cyanomethyl Oxime |
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| 引用本文： | 金蕾,方胡彪,曹成桥,黄年玉,邹坤,汪鋆植.Synthesis and Crystal Structure of （E）-2-phenyl-6,7dihydrobenzofuran-4（5H）-one O-cyanomethyl Oxime[J].结构化学,2013(9):1334-1338. |
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| 作者姓名： | 金蕾 方胡彪 曹成桥 黄年玉 邹坤 汪鋆植 |
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| 作者单位： | Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University;Hubei Tujia Institute of Medicine; |
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| 基金项目： | Supported by the National Natural Science Foundation of China（Nos.21102084,21272136,31070313）; Scientific and Technological Research Project of Hubei Provincial Department of Education（No.Q20111210）; Science Foundation of China Three Gorges University（No.KJ2010B001） |
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| 摘 要： | A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4（5H）-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data： monoclinic system,space group P21 /c,a = 8.423（8）,b = 19.596（16）,c = 8.770（8）,β = 107.750（12）°,V = 1379（2）3,Z = 4,F（000） = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections（Rint = 0.0782） and 2428 observed ones（I 2σ（I））.
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| 关 键 词： | 晶体结构 合成 苯基 X-射线单晶衍射 二氢苯并呋喃 核磁共振光谱 肟 氰 |
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