| Synthesis, Structure and Biological Activities of 2-Methylthio-3-cyano-7-（4-methoxyphenyl）- pyrazolo[1,5-a]pyrimidine |
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| 引用本文： | 李明,郭维斯,文丽荣,曲波.Synthesis, Structure and Biological Activities of 2-Methylthio-3-cyano-7-（4-methoxyphenyl）- pyrazolo[1,5-a]pyrimidine[J].结构化学,2006,25(1):108-112. |
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| 作者姓名： | 李明 郭维斯 文丽荣 曲波 |
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| 作者单位： | College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China，College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China，College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China，College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China |
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| 基金项目： | 中国科学院资助项目;教育部科学技术研究项目 |
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| 摘 要： | 1INTRODUCTION Pyrazolo1,5-a]pyrimidine derivatives have shown various biological activities in the terms of antibac-terial,antischistosomal and xanthine oxidase inhibi-tors1~5].The enaminones are highly reactive inter-mediates and have been extensively used as build-ing blocks in organic synthesis especially in the he-terocyclic compounds6~8].In addition,a great deal of interest has been focused on the synthesis of py-razolo1,5-a]pyrimidine through versatile enamino-nes because of thei…
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| 关 键 词： | 合成 结构分析 生物学性质 2-甲基硫代-3-蓝色-7-（4-甲氧基苯基）- 吡唑基[1 5-a]嘧啶 |
Synthesis, Structure and Biological Activities of 2-Methylthio-3-cyano-7-(4-methoxyphenyl)-pyrazolo[1,5-a]pyrimidine |
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| LI Ming,GUO Wei-Si,WEN Li-Rong,QU Bo.Synthesis, Structure and Biological Activities of 2-Methylthio-3-cyano-7-(4-methoxyphenyl)-pyrazolo[1,5-a]pyrimidine[J].Chinese Journal of Structural Chemistry,2006,25(1):108-112. |
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| Authors: | LI Ming GUO Wei-Si WEN Li-Rong QU Bo |
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| Institution: | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China |
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| Abstract: | The crystal structure of 2-methylthio-3-cyano-7-(4-methoxyphenyl)-pyrazolo1,5- a]-pyrimidine (C15H12N4OS, Mr = 296.35) has been determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic, space group P21/c with a = 9.200(3), b = 15.570(5), c = 11.125(4)(A),β= 114.273(6)°, V = 1452.7(8) (A)3, Z = 4, Dc = 1.355 g/cm3, μ= 0.227 mm-1, F(000) = 616, R = 0.0499 and wR = 0.0949 for 2947 unique reflections with 1633 observed ones (I > 2σ(I)). The results show that all ring atoms in the pyrazolopyrimidine moiety are almost coplanar with a strong tensile force, which might be an important active site. The preliminary biological test shows that the title compound has moderate herbicidal activities. |
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| Keywords: | pyrazolo[1 5-a]pyrimidine crystal structure synthesis herbicidal activities |
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