| A Structure-activity Relationship （SAR） Study of Fluoroquinolones with Biological Activity against Anti-S.pneumoniae |
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| 引用本文： | 李小红,张瑞州,程新路,杨向东.A Structure-activity Relationship （SAR） Study of Fluoroquinolones with Biological Activity against Anti-S.pneumoniae[J].结构化学,2006,25(1):33-40. |
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| 作者姓名： | 李小红 张瑞州 程新路 杨向东 |
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| 作者单位： | [1]Institute of Atom and Molecular Physics, Sichuan University, Chengdu 610065, China [2]Xinxiang Teacher＇s College, Xinxiang 453000, China |
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| 摘 要： | 1INTRODUCTION Streptococcus pneumoniae is a key pathogen in many respiratory tract infections.In a Canada-wide surveillance study published in1999,it was reported that21.2%of pneumococcal tested were interme-diately susceptible or resistant to penicillin.As the newer respiratory fluoroquinolones are active aga-inst both penicillin-susceptible and penicillin-resis-tant isolates of S.pneumoniae,they will be increa-singly important in the future treatment of infections caused by this pathoge…
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| 关 键 词： | 结构活性关联 DFT PCA HCA KNN 生物活性 反式-S肺炎体 药物研究 |
A Structure-activity Relationship(SAR)Study of Fluoroquinolones with Biological Activity against Anti-S.pneumoniae |
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| LI Xiao-Hong,ZHANG Rui-Zhou,CHENG Xin-Lu,YANG Xiang-Dong.A Structure-activity Relationship(SAR)Study of Fluoroquinolones with Biological Activity against Anti-S.pneumoniae[J].Chinese Journal of Structural Chemistry,2006,25(1):33-40. |
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| Authors: | LI Xiao-Hong ZHANG Rui-Zhou CHENG Xin-Lu YANG Xiang-Dong |
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| Abstract: | |
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| Keywords: | structure-activity relationship DFT PCA HCA KNN |
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