| Synthesis and Crystal Structure of 4-（2-Chlorophenyl）-5-cyano-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydropyrazolo[3,4-b]Pyridine under Microwave Irradiation |
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| 引用本文： | 朱松磊,屠树江,李团结,邹翔,章晓镜,纪顺俊,张勇.Synthesis and Crystal Structure of 4-（2-Chlorophenyl）-5-cyano-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydropyrazolo[3,4-b]Pyridine under Microwave Irradiation[J].结构化学,2004,23(11):1222-1225. |
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| 作者姓名： | 朱松磊 屠树江 李团结 邹翔 章晓镜 纪顺俊 张勇 |
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| 作者单位： | ZHU Song-Leia，b TU Shu-Jianga② LI Tuan-Jiea ZOU Xianga ZHANG Xiao-Jinga JI Shun-Junc ZHANG Yongc a (Department of Chemistry，Xuzhou Normal University，Key Laboratory of Biotechnology on Medical Plant，Xuzhou，Jiangsu 221116，China) b(Department of Chemistry，Xuzhou Medical College，Xuzhou，Jiangsu 221002，China) c (College of Chemistry and Chemical Engineering，Key Lab. of Org. Synth. of Jiangsu Province，Suzhou University，Suzhou，Jiangsu 215006，China) |
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| 基金项目： | This work was supported by the NNSFC (No. 20372057)，the NSF of Jiangsu Province (No. BK2001142)，the Open Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry and Chemical Engineering，Suzhou University (No. S |
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| 摘 要： | 1 INTRODUCTION The pyrazolo3,4-b]pyridine system has many interesting biological and pharmacological proper- ties, such as active antitubercular agents1, 2], active agents against gram positive and negative bacteria3], ACTH(Adrenocorticotropic hormone…
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| 关 键 词： | 合成 晶体结构 4-（2-氯苯）-5-氰基-3-甲基-6-氧-1-苯基-4 5 6 7-四氢吡唑[3 4-b]嘧啶 微波辐射 |
Synthesis and Crystal Structure of 4-(2- Chlorophenyl)-5-cyano-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydropyrazolo[3,4-b] Pyridine under Microwave Irradiation |
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| Abstract: | The title compound (C20H15ClN4O, Mr = 362.81) was synthesized by the reaction of ethyl 2-cyano-3-(2-chlorophenyl)-1-acylate with 5-amino-3-methyl-1-phenylpyrazole under microwave irradiation and its structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 8.8192(19), b = 15.976(3), c = 13.094(3) ? = 103.074(4), V = 1797.1(7) ?, Z = 4, Dc = 1.341 g/cm3, = 0.229 mm-1, F(000) = 752, R = 0.0632 and wR = 0.1278. X-ray analysis reveals that the pyridine ring adopts an envelope conformation. The dihedral angle between the pyrazole and pyridine planes is 2.19, and inter- molecular hydrogen bonds are also observed in the molecule. |
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| Keywords: | aminopyrazole pyrazolopyridine crystal structure microwave irradiation |
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