Reversed-phase separations on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase |
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| Authors: | J G Hou Y L Wang C X Li X Q Han J Z Gao J W Kang |
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| Institution: | (1) Institute of Chemistry, Northwest Normal University, 730070 Lanzhou, P.R. China;(2) Department of Chinese Herbs, Gansu Chinese Medicine College, 730000 Lanzhou, P.R. China;(3) Department of Chemistry, Guizhou Normal University, 550001 Guiyang, P.R. China |
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| Abstract: | Summary The chiral separation of eight racemic compounds has been investigated on a cellulose tris(3,5-dimethylphenylcarbamate) chiral
column under reversed-phase conditions. The discrimination mechanism under reversed-phase conditions is discussed. Addition
of acid to the mobile phase is necessary for resolution of acidic racemic compounds. The presence of ion-pair reagent in the
mobile phase is a key factor in the resolution of basic racemic compounds. Retention of the racemates is also affected by
addition of acid or salt. The anion in buffer not only interacts with the racemete, but also with the polysaccharide derivative
on the silica gel surface. |
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| Keywords: | Column liquid chromatography Chiral stationary phase Optical resolution Racemic compounds |
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